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EME - 16/33/01
Defining ARDS and sepsis sub-phenotypes: a re-analysis of two trials to inform stratified medicine approach with future trials
Project title: Defining ARDS and sepsis sub-phenotypes: a re-analysis of two trials to inform stratified medicine approach with future trials
Call to action: 16/67 16/67 Mechanisms of action of health interventions
Research type: Evidence Synthesis
Chief investigator: Professor Manu Shankar-Hari
Lead Author: Professor Manu Shankar-Hari
Contractor: Guy's and St Thomas' NHS Foundation Trust
Started: November 2017 | Status: Published August 2021
Sepsis and ARDS subphenotypes based on clinical, cytokines, organ injury markers and variations in risk of death at baseline were observed, with differences in treatment effect in the ARDS trial.
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