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Sepsis and ARDS subphenotypes based on clinical, cytokines, organ injury markers and variations in risk of death at baseline were observed, with differences in treatment effect in the ARDS trial.

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Manu Shankar-Hari, Shalini Santhakumaran, A Toby Prevost, Josie K Ward, Timothy Marshall, Claire Bradley, Carolyn S Calfee, Kevin L Delucchi, Pratik Sinha, Michael A Matthay, Jonathan Hackett, Cliona McDowell, John G Laffey, Anthony Gordon, Cecilia M O’Kane & Daniel F McAuley.

Manu Shankar-Hari 1,2,*, Shalini Santhakumaran 3, A Toby Prevost 3, Josie K Ward 4, Timothy Marshall 4, Claire Bradley 4, Carolyn S Calfee 5,6,7, Kevin L Delucchi 8, Pratik Sinha 5, Michael A Matthay 5, Jonathan Hackett 9, Cliona McDowell 10, John G Laffey 11, Anthony Gordon 4, Cecilia M O’Kane 12, Daniel F McAuley 9,10,12

1 Department of Intensive Care Medicine, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
2 School of Immunology and Microbial Sciences, King’s College London, London, UK
3 Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK
4 Intensive Care Unit, Imperial College/Charing Cross Hospital, London, UK
5 Department of Medicine, University of California, San Francisco, CA, USA
6 Department of Anaesthesia, University of California, San Francisco, CA, USA
7 Cardiovascular Research Institute, University of California, San Francisco, CA, USA
8 Department of Psychiatry, University of California, San Francisco, CA, USA
9 Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK
10 Northern Ireland Clinical Trials Unit, Royal Victoria Hospital, Belfast, UK
11 Anaesthesia, School of Medicine and Regenerative Medicine Institute (REMEDI), CÚRAM Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland
12 Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, UK
* Corresponding author Email:

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