A pragmatic single-blind randomised controlled trial and economic evaluation of the use of leukotriene receptor antagonists in primary care at steps 2 and 3 of the national asthma guidelines (ELEVATE study)

Price, D; Musgrave, S; Wilson, E; Sims, E; Shepstone, L; Blyth, A; Murdoch, J; Mugford, M; Juniper, E; Ayres, J; Wolfe, S; Freeman, D; Lipp, A; Gilbert, R; Harvey, I

doi:10.3310/hta15210

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Study found that leukotriene antagonists are unlikely to be a cost-effective alternative to inhaled corticosteroids, at 2005 prices, as initial asthma controller therapy at step 2 of the British Thoracic Society (BTS) guidelines, but evidence suggests that they are clinically equivalent to long-acting β2-agonists (LABAs) as add-on to inhaled corticosteroids in terms of quality of life as well as secondary measures; furthermore, they could be an alternative to LABAs at step 3 of the BTS guidelines

D Price, S Musgrave, E Wilson, E Sims, L Shepstone, A Blyth, J Murdoch, M Mugford, E Juniper, J Ayres, S Wolfe, D Freeman, A Lipp, R Gilbert & I Harvey.

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D Price ^1,^*, S Musgrave ², E Wilson ², E Sims ², L Shepstone ², A Blyth ², J Murdoch ³, M Mugford ², E Juniper ⁴, J Ayres ⁵, S Wolfe ⁶, D Freeman ⁷, A Lipp ⁸, R Gilbert ⁹, I Harvey ²

¹ Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK
² Norwich Medical School, University of East Anglia, Norwich, UK
³ School of Nursing and Midwifery, University of East Anglia, Norwich, UK
⁴ Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
⁵ School of Health & Population Sciences, University of Birmingham, Birmingham, UK
⁶ Thorpewood GP Surgery, Norwich, UK
⁷ Sheringham Medical Practice, Norfolk, UK
⁸ Great Yarmouth and Waveney Primary Care Trust, Norfolk, UK
⁹ Castle GP Partnership, Norwich, UK
^* Corresponding author Email: david@respiratoryresearch.org

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