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The WISE self-management intervention did not add value to existing care for any of the long-term conditions studied and further research is needed into key active components and facilitating contextual factors.

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David G Thompson 1, Sarah O’Brien 2, Anne Kennedy 3, Anne Rogers 3, Peter Whorwell 1, Karina Lovell 4, Gerry Richardson 5, David Reeves 6, Peter Bower 7,*, Carolyn Chew-Graham 8, Elaine Harkness 9, Paula Beech 10

1 Division of Diabetes, Endocrinology and Gastroenterology, University of Manchester, Manchester, UK
2 Institute of Infection and Global Health, University of Liverpool, Liverpool, UK
3 National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care Wessex, University of Southampton, Southampton, UK
4 Division of Nursing, Midwifery & Social Work, School of Health Sciences, University of Manchester, Manchester, UK
5 Centre for Health Economics, University of York, York, UK
6 Centre for Biostatistics, School of Health Sciences, University of Manchester, Manchester, UK
7 Centre for Primary Care, School of Health Sciences, University of Manchester, Manchester, UK
8 Research Institute, Primary Care and Health Sciences, Faculty of Medicine and Health Sciences, Keele University, Keele, UK
9 Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, UK
10 Stroke Rehabilitation Unit, Salford Royal Foundation Trust, Salford, UK
* Corresponding author Email: peter.bower@manchester.ac.uk

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