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This trial showed patients who discontinue long-term maintenance antidepressants are at increased risk of relapse and withdrawal symptoms, however, a substantial proportion of patients can discontinue antidepressants without relapse.
1 Division of Psychiatry, University College London, London, UK
2 Research Department of Primary Care and Population Health, University College London, London, UK
3 PRIMENT Clinical Trials Unit, University College London, London, UK
4 Comprehensive Clinical Trials Unit, University College London, London, UK
5 Department of Health and Social Care Sciences, University of York, York, UK
6 Primary Care Population Sciences and Medical Education, University of Southampton, Southampton, UK
7 Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
8 Department of Family Medicine, McMaster University, Hamilton, ON, Canada
9 Department of General Practice, University of Otago, Christchurch, New Zealand
* Corresponding author Email: larisa.duffy@ucl.ac.uk
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