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This trial showed patients who discontinue long-term maintenance antidepressants are at increased risk of relapse and withdrawal symptoms, however, a substantial proportion of patients can discontinue antidepressants without relapse.

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Larisa Duffy 1,*, Caroline S Clarke 2,3, Gemma Lewis 1, Louise Marston 2,3, Nick Freemantle 3,4, Simon Gilbody 5, Rachael Hunter 2,3, Tony Kendrick 6, David Kessler 7, Michael King 2,3, Paul Lanham 1, Dee Mangin 8,9, Michael Moore 6, Irwin Nazareth 2,3, Nicola Wiles 7, Faye Bacon 1, Molly Bird 1, Sally Brabyn 5, Alison Burns 7, Yvonne Donkor 1, Anna Hunt 6, Jodi Pervin 5, Glyn Lewis 1

1 Division of Psychiatry, University College London, London, UK
2 Research Department of Primary Care and Population Health, University College London, London, UK
3 PRIMENT Clinical Trials Unit, University College London, London, UK
4 Comprehensive Clinical Trials Unit, University College London, London, UK
5 Department of Health and Social Care Sciences, University of York, York, UK
6 Primary Care Population Sciences and Medical Education, University of Southampton, Southampton, UK
7 Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
8 Department of Family Medicine, McMaster University, Hamilton, ON, Canada
9 Department of General Practice, University of Otago, Christchurch, New Zealand
* Corresponding author Email:

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