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This trial found that tranexamic acid did not reduce death from gastrointestinal bleeding.

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Ian Roberts 1,*, Haleema Shakur-Still 1, Adefemi Afolabi 2, Adegboyega Akere 3, Monica Arribas 1, Emma Austin 1, Kiran Bal 1, Nuha Bazeer 4,5, Danielle Beaumont 1, Amy Brenner 1, Laura Carrington 1, Rizwana Chaudhri 6, Timothy Coats 7, Ian Gilmore 8, Kenneth Halligan 9, Irshad Hussain 10, Vipul Jairath 11, Kiran Javaid 12, Aasia Kayani 12, Ton Lisman 13, Raoul Mansukhani 1, Alec Miners 14, Muttiullah Mutti 15, Muhammad Arif Nadeem 16, Richard Pollok 17, Danielle Prowse 1, Jonathan Simmons 18, Simon Stanworth 19,20,21, Andrew Veitch 22, Jack Williams 14

1 Clinical Trials Unit, London School of Hygiene & Tropical Medicine, London, UK
2 Department of Surgery, University College Hospital Ibadan, Ibadan, Nigeria
3 Department of Medicine, University College Hospital Ibadan, Ibadan, Nigeria
4 Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK
5 Department of Health Policy, London School of Economics and Political Science, London, UK
6 Department of Obstetrics and Gynaecology, Rawalpindi Medical University, Rawalpindi, Pakistan
7 Emergency Department, Leicester Royal Infirmary, Leicester, UK
8 Liverpool Centre for Alcohol Research, University of Liverpool, Liverpool, UK
9 Patient representative, UK, ,
10 Department of Medicine, King Edward Medical University, Mayo Hospital, Lahore, Pakistan
11 Division of Gastroenterology, Western University and London Health Sciences Centre, London, ON, Canada
12 Rawalpindi Medical University – Pakistan National Coordinating Centre (RMU-PNCC), Rawalpindi, Pakistan
13 Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
14 Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK
15 Department of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan
16 Medical Unit III, Services Institute of Medical Sciences, Services Hospital Gastrointestinal, Lahore, Pakistan
17 Gastroenterology and Hepatology Department, St George’s Hospital, London, UK
18 Gastroenterology Department, Royal Berkshire Hospital, Reading, UK
19 Transfusion Medicine, NHS Blood and Transplant (NHSBT), John Radcliffe Hospital, Oxford, UK
20 Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK
21 Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
22 Gastroenterology Department, New Cross Hospital, Wolverhampton, UK
* Corresponding author Email: Ian.Roberts@lshtm.ac.uk

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