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This trial showed that aflibercept is non-inferior to ranibizumab, but could not demonstrate that bevacizumab is non-inferior to ranibizumab or aflibercept, although bevacizumab is considerably cheaper than either.

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Philip Hykin 1,2,*, A Toby Prevost 3, Sobha Sivaprasad 1,2, Joana C Vasconcelos 3, Caroline Murphy 4, Joanna Kelly 4, Jayashree Ramu 1, Abualbishr Alshreef 5, Laura Flight 5, Rebekah Pennington 5, Barry Hounsome , Ellen Lever 4, Andrew Metry 5, Edith Poku 5, Yit Yang 6, Simon P Harding 7, Andrew Lotery 8, Usha Chakravarthy 9, John Brazier 5

1 National Institute for Health Research Moorfields Biomedical Research Centre, London, UK
2 Institute of Ophthalmology, University College London, London, UK
3 Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK
4 King’s Clinical Trials Unit at King’s Health Partners, King’s College London, London, UK
5 School of Health and Related Research, University of Sheffield, Sheffield, UK
6 The Eye Infirmary, New Cross Hospital, Wolverhampton, UK
7 Eye and Vision Science, University of Liverpool, and St Paul’s Eye Unit, Royal Liverpool University Hospitals, Liverpool, UK
8 Faculty of Medicine, University of Southampton, Southampton, UK
9 Department of Biomedical Sciences, Queen’s University Belfast, Belfast, UK
* Corresponding author Email:

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