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Bisphosphonates increased bone mineral density for people with stage 3B+ chronic kidney disease but demonstrated renal toxicity, while failing to demonstrate antifracture effectiveness, and further research is needed.

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Danielle E Robinson 1,, M Sanni Ali 1,2,, Victoria Y Strauss 1,*, Leena Elhussein 1, Bo Abrahamsen 3,4, Nigel K Arden 5,6, Yoav Ben-Shlomo 7, Fergus Caskey 8,9, Cyrus Cooper 1,6, Daniel Dedman 10, Antonella Delmestri 1, Andrew Judge 1,11,12, Muhammad Kassim Javaid 1,6, Daniel Prieto-Alhambra 1,13

1 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Oxford, Oxford, UK
2 Faculty of Epidemiology and Population Health, Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK
3 Open Patient data Explorative Network (OPEN), Department of Clinical Research, University of Southern Denmark, Odense, Denmark
4 Department of Medicine, Holbæk Hospital, Holbæk, Denmark
5 Arthritis Research UK Sports, Exercise and Osteoarthritis Centre, University of Oxford, Oxford, UK
6 Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
7 Population Health Sciences, University of Bristol, Bristol, UK
8 School of Social and Community Medicine, University of Bristol, Bristol, UK
9 UK Renal Registry, Bristol, UK
10 Clinical Practice Research Datalink, Medicines and Healthcare products Regulatory Agency, London, UK
11 Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
12 National Institute for Health Research (NIHR) Bristol Biomedical Research Centre (BRC), University Hospitals Bristol NHS Foundation Trust, University of Bristol, Southmead Hospital, Bristol, UK
13 Grup de Recerca en Malalties Prevalents de l’Aparell Locomotor (GREMPAL) Research Group and Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFes), University Institute for Primary Care Research (IDIAP) Jordi Gol, Universitat Autonoma de Barcelona and Instituto de Salud Carlos III, Barcelona, Spain
* Corresponding author Email: victoria.strauss@csm.ox.ac.uk

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