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A series of N-of-1 RCTs found no overall effect of 20mg Atorvastatin on muscle symptoms when compared to placebo.

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Emily Herrett 1, Elizabeth Williamson 2, Kieran Brack 3, Alexander Perkins 4, Andrew Thayne 4, Haleema Shakur-Still 4, Ian Roberts 4, Danielle Prowse 4, Danielle Beaumont 4, Zahra Jamal 4, Ben Goldacre 5, Tjeerd van Staa 6, Thomas M MacDonald 7, Jane Armitage 8, Michael Moore 9, Maurice Hoffman 10, Liam Smeeth 1,*

1 Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK
2 Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK
3 Liver Research, King’s College Hospital, London, UK
4 Clinical Trials Unit, London School of Hygiene & Tropical Medicine, London, UK
5 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
6 Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, UK
7 Medicines Monitoring Unit, School of Medicine, University of Dundee, Dundee, UK
8 Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
9 School of Primary Care and Population Sciences, University of Southampton, Southampton, UK
10 , London, UK
* Corresponding author Email:

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