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This study found a trial comparing psychological interventions with antipsychotic medication and a combination treatment in young people with psychosis is feasible with some adaptations to the design.

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Anthony P Morrison 1,2,*, Melissa Pyle 1,2, Rory Byrne 1,2, Matthew Broome 3,4,5,6, Daniel Freeman 4,6, Louise Johns 4,6, Anthony James 4,6, Nusrat Husain 2,7, Richard Whale 8, Graeme MacLennan 9, John Norrie 10, Jemma Hudson 9, Sarah Peters 2, Linda Davies 2, Samantha Bowe 1, Jo Smith 11, David Shiers 1,2, Emmeline Joyce 1, Wendy Jones 1,2, Chris Hollis 12, Daniel Maughan 6

1 Psychosis Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK
2 Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
3 Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK
4 Department of Psychiatry, Medical Sciences Division, University of Oxford, Oxford, UK
5 Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK
6 Warneford Hospital, Oxford Health NHS Foundation Trust, Oxford, UK
7 Early Intervention in Psychosis Service, Lancashire and South Cumbria NHS Foundation Trust, Chorley, UK
8 Brighton and Sussex Medical School, University of Sussex, Brighton, UK
9 Health Services Research Unit, University of Aberdeen, Aberdeen, UK
10 Clinical Trials Unit, University of Edinburgh, Edinburgh, UK
11 School of Allied Health and Community, University of Worcester, Worcester, UK
12 National Institute for Health Research MindTech MedTech Co-operative, Division of Psychiatry and Applied Psychology, Institute of Mental Health, University of Nottingham, Nottingham, UK
* Corresponding author Email: anthony.p.morrison@manchester.ac.uk

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