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Reluctance of staff to discuss sexual side effects and patient concerns about switching medication led to low recruitment and the trial being stopped after an extended pilot phase.

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Michael J Crawford 1,*, Lavanya Thana 1, Rachel Evans 2, Alexandra Carne 3, Lesley O’Connell 1, Amy Claringbold 1, Arunan Saravanamuthu 4, Rebecca Case 4, Jasna Munjiza 1,4, Sandra Jayacodi 4, Joseph G Reilly 3, Elizabeth Hughes 5, Zoe Hoare 2, Barbara Barrett 6, Verity C Leeson 1, Carol Paton 7, Patrick Keown 8, Sofia Pappa 1,9, Charlotte Green 4, Thomas RE Barnes 1

1 Division of Psychiatry, Imperial College London, London, UK
2 North Wales Organisation for Randomised Trials in Health and Social Care, University of Bangor, Bangor, UK
3 Tees, Esk and Wear Valleys NHS Foundation Trust, Darlington, UK
4 Central and North West London NHS Foundation Trust, London, UK
5 School of Healthcare, University of Leeds, Leeds, UK
6 Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
7 Oxleas NHS Foundation Trust, Kent, UK
8 Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK
9 West London NHS Trust, London, UK
* Corresponding author Email:

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