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At 10-year median follow-up, there was no difference in disease-specific mortality between active monitoring, radical prostatectomy and radical radiotherapy treatments, which caused different side-effect profiles.

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Freddie C Hamdy 1,*, Jenny L Donovan 2, J Athene Lane 2, Malcolm Mason 3, Chris Metcalfe 2, Peter Holding 1, Julia Wade 2, Sian Noble 2, Kirsty Garfield 2, Grace Young 2, Michael Davis 2, Tim J Peters 2, Emma L Turner 2, Richard M Martin 2, Jon Oxley 4, Mary Robinson 5, John Staffurth 6, Eleanor Walsh 2, Jane Blazeby 2, Richard Bryant 1, Prasad Bollina 7, James Catto 8, Andrew Doble 9, Alan Doherty 10, David Gillatt 11, Vincent Gnanapragasam 9, Owen Hughes 12, Roger Kockelbergh 13, Howard Kynaston 12, Alan Paul 14, Edgar Paez 15, Philip Powell 15, Stephen Prescott 14, Derek Rosario 8, Edward Rowe 11, David Neal 1,16

1 Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
2 Bristol Medical School, University of Bristol, Bristol, UK
3 School of Medicine, University of Cardiff, Cardiff, UK
4 Department of Cellular Pathology, North Bristol NHS Trust, Bristol, UK
5 Department of Cellular Pathology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
6 Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK
7 Department of Urology and Surgery, Western General Hospital, University of Edinburgh, Edinburgh, UK
8 Academic Urology Unit, University of Sheffield, Sheffield, UK
9 Department of Urology, Addenbrooke’s Hospital, Cambridge, UK
10 Department of Urology, Queen Elizabeth Hospital, Birmingham, UK
11 Department of Urology, Southmead Hospital and Bristol Urological Institute, Bristol, UK
12 Department of Urology, Cardiff and Vale University Health Board, Cardiff, UK
13 Department of Urology, University Hospitals of Leicester, Leicester, UK
14 Department of Urology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
15 Department of Urology, Freeman Hospital, Newcastle upon Tyne, UK
16 Academic Urology Group, University of Cambridge, Cambridge, UK
* Corresponding author Email: Freddie.Hamdy@nds.ox.ac.uk

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