C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT

Francis, Nick A; Gillespie, David; White, Patrick; Bates, Janine; Lowe, Rachel; Sewell, Bernadette; Phillips, Rhiannon; Stanton, Helen; Kirby, Nigel; Wootton, Mandy; Thomas-Jones, Emma; Hood, Kerenza; Llor, Carl; Cals, Jochen; Melbye, Hasse; Naik, Gurudutt; Gal, Micaela; Fitzsimmons, Deborah; Alam, Mohammed Fasihul; Riga, Evgenia; Cochrane, Ann; Butler, Christopher C

doi:10.3310/hta24150

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Point-of-care testing resulted in a 20% absolute reduction in patient-reported antibiotic consumption over 4 weeks, without impairing chronic obstructive pulmonary disease health status.

Nick A Francis , David Gillespie , Patrick White , Janine Bates , Rachel Lowe , Bernadette Sewell , Rhiannon Phillips , Helen Stanton , Nigel Kirby , Mandy Wootton , Emma Thomas-Jones , Kerenza Hood , Carl Llor , Jochen Cals , Hasse Melbye , Gurudutt Naik , Micaela Gal , Deborah Fitzsimmons , Mohammed Fasihul Alam , Evgenia Riga , Ann Cochrane & Christopher C Butler .

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Nick A Francis ^1,^*, David Gillespie ², Patrick White ³, Janine Bates ², Rachel Lowe ², Bernadette Sewell ⁴, Rhiannon Phillips ¹, Helen Stanton ², Nigel Kirby ², Mandy Wootton ⁵, Emma Thomas-Jones ², Kerenza Hood ², Carl Llor ⁶, Jochen Cals ⁷, Hasse Melbye ⁸, Gurudutt Naik ⁹, Micaela Gal ¹⁰, Deborah Fitzsimmons ⁴, Mohammed Fasihul Alam ¹¹, Evgenia Riga ¹², Ann Cochrane ³, Christopher C Butler ¹³

¹ Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK
² South East Wales Trials Unit, Centre for Trials Research, Cardiff University, Cardiff, UK
³ Department of Primary Care & Public Health Sciences, King’s College London, London, UK
⁴ Swansea Centre for Health Economics, College of Human and Health Sciences, Swansea University, Swansea, UK
⁵ Specialist Antimicrobial Chemotherapy Unit, University Hospital of Wales, Cardiff, UK
⁶ University Institute in Primary Care Research Jordi Gol, Via Roma Health Centre, Barcelona, Spain
⁷ Department of Family Medicine, CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands
⁸ General Practice Research Unit, Department of Community Medicine, Faculty of Health Sciences, University of Tromsø – The Arctic University of Norway, Tromsø, Norway
⁹ Department of Wound Healing, University Hospital Wales, Cardiff, UK
¹⁰ Wales Primary and Emergency Care Research Centre, Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK
¹¹ Department of Public Health, College of Health Sciences, Qatar University, Doha, Qatar
¹² Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
¹³ Primary Care and Vaccines Collaborative Clinical Trials Unit, University of Oxford, John Radcliffe Hospital, Oxford, UK
^* Corresponding author Email: francisna@cardiff.ac.uk

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