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This study assessed key operational aspects of study design needed to determine the correlates of protection against invasive group B streptococcus and confirmed that a full study is feasible.

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Clara Carreras-Abad 1, Madeleine Cochet 1, Tom Hall 1, Laxmee Ramkhelawon 1, Asma Khalil 2, Elisabeth Peregrine 3, Latha Vinayakarao 4, Sharmila Sivarajan 5, Rosol Hamid 6, Tim Planche 7, Elizabeth Sheridan 8, Stephen Winchester 9, Jane Plumb 10, Abdelmajid Djennad 11, Nick Andrews 11, Kirsty Le Doare 1,*, Paul Heath 1

1 Paediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, St George’s, University of London, London, UK
2 Department of Obstetrics and Gynaecology, St George’s University Hospitals NHS Foundation Trust, London, UK
3 Department of Obstetrics and Gynaecology, Kingston Hospital NHS Foundation Trust, London, UK
4 Department of Obstetrics and Gynaecology, Poole Hospital NHS Foundation Trust, Poole, UK
5 Department of Obstetrics and Gynaecology, Surrey and Sussex Healthcare NHS Trust, Redhill, UK
6 Department of Obstetrics and Gynaecology, Croydon Health Services NHS Trust, Croydon, UK
7 Microbiology Department, St George’s University Hospitals NHS Foundation Trust, London, UK
8 Microbiology Department, Poole Hospital NHS Foundation Trust, Poole, UK
9 Microbiology Department, Surrey and Sussex Healthcare NHS Trust, Redhill, UK
10 Group B Strep Support Group, Haywards Heath, UK
11 Statistics, Modelling and Economics Department, National Infection Service, Public Health England, London, UK
* Corresponding author Email: k.ledoare@nhs.net

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