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A protocolised non-invasive weaning strategy did not reduce time to liberation from ventilation, although there were other possible advantages for patients.

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Gavin D Perkins 1,2,*, Dipesh Mistry 1, Ranjit Lall 1, Fang Gao-Smith 2, Catherine Snelson 3, Nicholas Hart 4,5, Luigi Camporota 5, James Varley 6, Coralie Carle 7, Elankumaran Paramasivam 8, Beverly Hoddell 1, Adam de Paeztron 1, Sukhdeep Dosanjh 1, Julia Sampson 1,2, Laura Blair 1, Keith Couper 1,2, Daniel McAuley 9, J Duncan Young 10, Tim Walsh 11, Bronagh Blackwood 9, Louise Rose 12, Sarah E Lamb 1, Melina Dritsaki 1, Mandy Maredza 1, Iftekhar Khan 1,13, Stavros Petrou 1, Simon Gates 1

1 Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
2 Critical Care Unit, Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
3 Department of Critical Care, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
4 Division of Asthma, Allergy and Lung Biology, King’s College London, London, UK
5 Guy’s and St Thomas’ Foundation Trust, King’s College London, London, UK
6 Department of Critical Care, Addenbrooke’s Hospital, Cambridge University Hospitals, Cambridge, UK
7 Department of Critical Care, Peterborough City Hospital, Peterborough, UK
8 Department of Critical Care, Leeds Teaching Hospitals, Leeds, UK
9 School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine Institute for Health Sciences, Queen’s University Belfast, Belfast, UK
10 Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, UK
11 Anaesthesia, Critical Care and Pain Medicine, Division of Health Sciences, The University of Edinburgh, Edinburgh, UK
12 Faculty of Nursing, University of Toronto, Toronto, ON, Canada
13 Population and Patient Health, King’s College London, London, UK
* Corresponding author Email: G.D.Perkins@warwick.ac.uk

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