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In this large trial, although tranexamic acid was safe, there was no significant difference in functional status 90 days after intracerebral haemorrhage.

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Nikola Sprigg 1,2,*, Katie Flaherty 1, Jason P Appleton 1, Rustam Al-Shahi Salman 3, Daniel Bereczki 4, Maia Beridze 5, Alfonso Ciccone 6, Ronan Collins 7, Robert A Dineen 8,9, Lelia Duley 10, Juan José Egea-Guerrero 11, Timothy J England 12, Michal Karlinski 13, Kailash Krishnan 1,2, Ann Charlotte Laska 14, Zhe Kang Law 1,2,15, Christian Ovesen 16, Serefnur Ozturk 17, Stuart J Pocock 18, Ian Roberts 19, Thompson G Robinson 20, Christine Roffe 21, Nils Peters 22, Polly Scutt 1, Jegan Thanabalan 23, David Werring 24,25, David Whynes 26, Lisa Woodhouse 1, Philip M Bath 1,2,

1 Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK
2 Stroke, Nottingham University Hospitals NHS Trust, Nottingham, UK
3 Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
4 Department of Neurology, Semmelweis University, Budapest, Hungary
5 The First University Clinic of Tbilisi State Medical University, Tbilisi, Georgia
6 Neurology Unit, Azienda Socio Sanitaria Territoriale di Mantova, Mantua, Italy
7 Stroke Service, Adelaide and Meath Hospital, Tallaght, Ireland
8 Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK
9 NIHR Nottingham Biomedical Research Centre, Nottingham, UK
10 Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, UK
11 UGC de Medicina Intensiva, Hospital Universitario Virgen del Rocío, IBiS/CSIC/Universidad de Sevilla, Seville, Spain
12 Vascular Medicine, Division of Medical Sciences & GEM, University of Nottingham, Derby, UK
13 Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
14 Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
15 Department of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia
16 Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Department of Neurology, Copenhagen, Denmark
17 Department of Neurology, Selcuk University Medical Faculty, Konya, Turkey
18 Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK
19 Clinical Trials Unit, London School of Hygiene & Tropical Medicine, London, UK
20 Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
21 Stroke Research, Faculty of Medicine and Health Sciences, Keele University, Keele, UK
22 Department of Neurology and Stroke Center, University Hospital Basel, Basel, Switzerland
23 Division of Neurosurgery, Department of Surgery, National University of Malaysia, Kuala Lumpur, Malaysia
24 Stroke Research Centre, University College London Queen Square Institute of Neurology, Faculty of Brain Sciences of University College London, University College London, London, UK
25 National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK
26 School of Economics, University of Nottingham, Nottingham, UK
* Corresponding author Email: Nikola.sprigg@nottingham.ac.uk

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