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Vitamin D supplementation reduced the risk of acute respiratory infections, with very vitamin D deficient people and those receiving daily or weekly doses experiencing the most benefit.

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Adrian R Martineau 1,2,*, David A Jolliffe 1, Lauren Greenberg 1, John F Aloia 3, Peter Bergman 4, Gal Dubnov-Raz 5, Susanna Esposito 6, Davaasambuu Ganmaa 7, Adit A Ginde 8, Emma C Goodall 9, Cameron C Grant 10, Wim Janssens 11, Megan E Jensen 12, Conor P Kerley 13, Ilkka Laaksi 14, Semira Manaseki-Holland 15, David Mauger 16, David R Murdoch 17, Rachel Neale 18, Judy R Rees 19, Steve Simpson 20, Iwona Stelmach 21, Geeta Trilok Kumar 22, Mitsuyoshi Urashima 23, Carlos A Camargo 24, Christopher J Griffiths 1,2,25, Richard L Hooper 1

1 Centre for Primary Care and Public Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
2 Asthma UK Centre for Applied Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
3 Bone Mineral Research Center, Winthrop University Hospital, Mineola, NY, USA
4 Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
5 Deptartment of Exercise, Lifestyle and Nutrition Clinic, Edmond and Lily Safra Children’s Hospital, Tel Hashomer, Israel
6 Pediatric Highly Intensive Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy
7 Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
8 Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA
9 Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
10 Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
11 Universitaire ziekenhuizen Leuven, Leuven, Belgium
12 Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, NSW, Australia
13 Dublin City University, Dublin, Ireland
14 Centre for Military Medicine, Finnish Defense Forces, University of Tampere, Tampere, Finland
15 Department of Public Health, Epidemiology and Biostatistics, Institute of Applied Health Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
16 Department of Statistics, The Pennsylvania State University, Hershey, PA, USA
17 Department of Pathology, University of Otago, Christchurch, New Zealand
18 Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, QLD, Australia
19 Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
20 Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia
21 Department of Pediatrics and Allergy, Medical University of Łódź, Łódź, Poland
22 Institute of Home Economics, University of Delhi, New Delhi, India
23 Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan
24 Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
25 Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
* Corresponding author Email: a.martineau@qmul.ac.uk

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