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An asthma self-management plan that advised patients to temporarily quadruple their dose of inhaled corticosteroid reduced asthma exacerbations, with fewer serious adverse events and at lower cost.

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Tricia McKeever 1, Kevin Mortimer 2, Lucy Bradshaw 3, Rebecca Haydock 3, Ian Pavord 4, Bernard Higgins 5, Samantha Walker 6, Andrew Wilson 7, David Price 8,9, Mike Thomas 10, Graham Devereux 8, Christopher Brightling 7, Charlotte Renwick 11, Steve Parrott 11, Eleanor Mitchell 3, Lelia Duley 3, Tim Harrison 1,*

1 Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK
2 Liverpool School of Tropical Medicine, University of Liverpool, Liverpool, UK
3 Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, UK
4 Respiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK
5 Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
6 Asthma UK, London, UK
7 University of Leicester, Leicester, UK
8 University of Aberdeen, Aberdeen, UK
9 Observational and Pragmatic Research Institute, , Singapore
10 University of Southampton, Southampton, UK
11 University of York, York, UK
* Corresponding author Email: tim.harrison@nottingham.ac.uk

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