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Adding multiparametric MRI as an initial test prior to prostate biopsy can reduce the proportion of men having unnecessary biopsies and improve the detection of clinically significant prostate cancer.

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Louise Clare Brown 1, Hashim U Ahmed 2,3,*, Rita Faria 4, Ahmed El-Shater Bosaily 2,3, Rhian Gabe 5, Richard S Kaplan 1, Mahesh Parmar 1, Yolanda Collaco-Moraes 1, Katie Ward 1, Richard Graham Hindley 6, Alex Freeman 7, Alexander Kirkham 8, Robert Oldroyd 9, Chris Parker 10, Simon Bott 11, Nick Burns-Cox 12, Tim Dudderidge 13, Maneesh Ghei 14, Alastair Henderson 15, Rajendra Persad 16, Derek J Rosario 17, Iqbal Shergill 18, Mathias Winkler 19, Marta Soares 4, Eldon Spackman 4, Mark Sculpher 4, Mark Emberton 2,3

1 Medical Research Council Clinical Trials Unit, University College London, London, UK
2 Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, UK
3 Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK
4 Centre for Health Economics, University of York, York, UK
5 Hull York Medical School and Department of Health Sciences, University of York, York, UK
6 Department of Urology, Hampshire Hospitals NHS Foundation Trust, Basingstoke, UK
7 Department of Histopathology, University College London Hospitals NHS Foundation Trust, London, UK
8 Department of Radiology, University College London Hospitals NHS Foundation Trust, London, UK
9 Public and patient representative, Nottingham, UK
10 Department of Academic Urology, Royal Marsden Hospital, Sutton, UK
11 Frimley Park Hospital, Frimley, UK
12 Musgrove Park Hospital, Taunton, UK
13 Southampton General Hospital, Southampton, UK
14 Department of Urology, Whittington Hospital, London, UK
15 Maidstone Hospital, Maidstone, UK
16 Bristol Urological Institute, Southmead Hospital, Bristol, UK
17 Royal Hallamshire Hospital, Sheffield, UK
18 Wrexham Maelor Hospital, Wrexham, UK
19 Charing Cross Hospital, Imperial College London, London, UK
* Corresponding author Email: hashim.ahmed@imperial.ac.uk

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