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Continuous low-dose antibiotic prophylaxis reduced the frequency of symptomatic, antibiotic-treated urinary tract infection by 48%, although antimicrobial resistance of bacteria isolated from the urine of those taking prophylaxis increased.

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Robert Pickard 1,*,, Thomas Chadwick 2, Yemi Oluboyede 2, Catherine Brennand 3, Alexander von Wilamowitz-Moellendorff 3, Doreen McClurg 4, Jennifer Wilkinson 3, Laura Ternent 2, Holly Fisher 2, Katherine Walton 5, Elaine McColl 2, Luke Vale 2, Ruth Wood 3, Mohamed Abdel-Fattah 6, Paul Hilton 7, Mandy Fader 8, Simon Harrison 9, James Larcombe 10, Paul Little 11, Anthony Timoney 12, James N’Dow 6, Heather Armstrong 13, Nicola Morris 12, Kerry Walker 4, Nikesh Thiruchelvam 14

1 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
2 Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
3 Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK
4 Nursing, Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Glasgow, UK
5 Department of Microbiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, UK
6 Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK
7 Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
8 Health Sciences, University of Southampton, Southampton, UK
9 Department of Urology, Mid-Yorkshire Hospitals NHS Trust, Pinderfields Hospital, Wakefield, UK
10 Skerne Medical Centre, Sedgefield, UK
11 Primary Care and Population Sciences, University of Southampton, Southampton, UK
12 Bristol Urological Institute, North Bristol NHS Trust, Bristol, UK
13 Patient representative, no affiliation, ,
14 Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
* Corresponding author Email: robert.pickard@newcastle.ac.uk

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