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A large trial comparing the effects of prolonged release metformin and placebo on risk of cardiovascular disease events is potentially feasible.

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Simon J Griffin 1,2,*, M Angelyn Bethel 3, Rury R Holman 3, Kamlesh Khunti 4, Nicholas Wareham 1, Gwen Brierley 1, Melanie Davies 4, Andrew Dymond 1, Rose Eichenberger 1, Philip Evans 5, Alastair Gray 6, Colin Greaves 5, Kyla Harrington 4, Graham Hitman 7, Greg Irving 2, Sarah Lessels 3, Ann Millward 5, John R Petrie 8, Martin Rutter 9, Mike Sampson 10,11, Naveed Sattar 8, Stephen Sharp 1

1 Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK
2 Institute of Public Health, University of Cambridge, Cambridge, UK
3 Diabetes Trials Unit, University of Oxford, Oxford, UK
4 Diabetes Research Centre, University of Leicester, Leicester, UK
5 University of Exeter Medical School, Exeter, UK
6 Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK
7 Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
8 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
9 Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
10 Norwich Medical School, University of East Anglia, Norwich, UK
11 Department of Diabetes, Endocrinology and General Medicine, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK
* Corresponding author Email:

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