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This trial of adding amisulpride in clozapine-unresponsive schizophrenia under-recruited and did not show any statistically significant response at 12 weeks.

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Thomas RE Barnes 1,2,*, Verity C Leeson 1, Carol Paton 1,3, Louise Marston 4,5, Linda Davies 6, William Whittaker 6, David Osborn 7,8, Raj Kumar 9, Patrick Keown 10,11, Rameez Zafar 12, Khalid Iqbal 13, Vineet Singh 14, Pavel Fridrich 15, Zachary Fitzgerald 16, Hemant Bagalkote 17, Peter M Haddad 18,19, Mariwan Husni 20,21, Tim Amos 22,23

1 Centre for Mental Health, Imperial College London, London, UK
2 West London Mental Health NHS Trust, London, UK
3 Oxleas NHS Foundation Trust, London, UK
4 Department of Primary Care and Population Health, University College London, London, UK
5 PRIMENT Clinical Trials Unit, University College London, London, UK
6 Centre for Health Economics, Institute of Population Health, University of Manchester, Manchester, UK
7 Division of Psychiatry, University College London, London, UK
8 Camden and Islington NHS Foundation Trust, London, UK
9 Tees, Esk and Wear Valley NHS Foundation Trust, Billingham, UK
10 Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK
11 Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
12 Lincolnshire Partnership NHS Foundation Trust, Lincoln, UK
13 Bradford District Care Trust, Bradford, UK
14 Derbyshire Healthcare NHS Foundation Trust, Derby, UK
15 North Essex Partnership University NHS Foundation Trust, Chelmsford, UK
16 Manchester Mental Health and Social Care NHS Trust, Manchester, UK
17 Nottinghamshire Healthcare NHS Foundation Trust, Nottingham, UK
18 Greater Manchester West Mental Health NHS Foundation Trust, Manchester, UK
19 Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK
20 Central and North West London NHS Foundation Trust, London, UK
21 Northern Ontario School of Medicine, Sudbury, ON, Canada
22 Avon and Wiltshire Mental Health Partnership NHS Trust, Bristol, UK
23 School of Social and Community Medicine, University of Bristol, Bristol, UK
* Corresponding author Email: t.r.barnes@imperial.ac.uk

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