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This feasibility study established a potential design for an RCT of early switching from intravenous to oral antibiotics for children with acute osteomyelitis or septic arthritis.

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Hans de Graaf 1,2, Priya Sukhtankar 1,2, Barbara Arch 3, Nusreen Ahmad 1,2,4, Amanda Lees 5, Abigail Bennett 3, Catherine Spowart 3, Helen Hickey 3, Annmarie Jeanes 6, Kate Armon 7, Andrew Riordan 8, Jethro Herberg 9, Scott Hackett 10, Carrol Gamble 3, Delane Shingadia 11, Ann Pallett 2, Stuart C Clarke 12, Philip Henman 13, Marieke Emonts 13, Mike Sharland 14, Adam Finn 15,16, Andrew J Pollard 17, Colin Powell 18,19, Peter Marsh 20, Claire Ballinger 21, Paula R Williamson 3, Nicholas MP Clarke 2,22, Saul N Faust 1,2,*

1 National Institute for Health Research Wellcome Trust Clinical Research Facility, University of Southampton, Southampton, UK
2 University Hospital Southampton NHS Foundation Trust, Southampton, UK
3 Medicines for Children Clinical Trials Unit, Clinical Trials Research Centre, Department of Biostatistics, University of Liverpool, Liverpool, UK
4 Public Health England, Southampton, UK
5 Health and Wellbeing Research and Development Group, University of Winchester, Winchester, UK
6 Radiology, Leeds Children’s Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK
7 Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK
8 Alder Hey Children’s NHS Foundation Trust, Liverpool, UK
9 Section of Paediatrics, Imperial College London, St Mary’s Campus, London, UK
10 Heart of England NHS Foundation Trust, Birmingham, UK
11 Paediatric Infectious Diseases, Great Ormond Street Hospital for Children, London, UK
12 Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
13 Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK
14 St George’s University Hospitals NHS Foundation Trust, London, UK
15 Bristol Children’s Vaccine Centre, School of Clinical Sciences, University of Bristol, Bristol, UK
16 Paediatric Infectious Diseases and Immunology, Bristol Royal Hospital for Children, Bristol, UK
17 Department of Paediatrics, Medical Sciences Division, University of Oxford, Oxford, UK
18 School of Medicine, University of Cardiff, Cardiff, UK
19 Department of Paediatrics, University Hospital of Wales, Cardiff, UK
20 Public Health England, South East Public Health England Regional Laboratory, Southampton, UK
21 Faculty of Health Sciences, University of Southampton, Southampton, UK
22 Paediatric Orthopaedics, University of Southampton, Southampton, UK
* Corresponding author Email: s.faust@soton.ac.uk

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