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The core outcomes set in disease modification trials in mild to moderate dementia should include cognition markers for all trial participants and a structural MRI scan for a subset.

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Lucy Webster 1, Derek Groskreutz 2, Anna Grinbergs-Saull 3, Rob Howard 1, John T O’Brien 4, Gail Mountain 5, Sube Banerjee 6, Bob Woods 7, Robert Perneczky 8, Louise Lafortune 9, Charlotte Roberts 10, Jenny McCleery 11, James Pickett 3, Frances Bunn 12, David Challis 13, Georgina Charlesworth 14, Katie Featherstone 15, Chris Fox 16, Claire Goodman 12, Roy Jones 17, Sallie Lamb 18, Esme Moniz-Cook 19, Justine Schneider 20, Sasha Shepperd 21, Claire Surr 22, Jo Thompson-Coon 23, Clive Ballard 24, Carol Brayne 9, Orlaith Burke 21, Alistair Burns 25, Linda Clare 23,26,27, Peter Garrard 28, Patrick Kehoe 29, Peter Passmore 30, Clive Holmes 31, Ian Maidment 32, Fliss Murtagh 33, Louise Robinson 34, Gill Livingston 1,35,36,*

1 Division of Psychiatry, University College London, London, UK
2 Division of Psychology and Language Sciences, University College London, London, UK
3 Alzheimer’s Society, London, UK
4 Department of Psychiatry, University of Cambridge, Cambridge, UK
5 School of Health and Related Research, University of Sheffield, Sheffield, UK
6 Brighton and Sussex Medical School, University of Sussex, Brighton, UK
7 Dementia Services Development Centre Wales, Bangor University, Bangor, UK
8 Faculty of Medicine, School of Public Health, Imperial College London, London, UK
9 Cambridge Institute of Public Health, University of Cambridge, Cambridge, UK
10 International Consortium for Health Outcomes Measurement, London, UK
11 Oxford Health NHS Foundation Trust, Banbury, UK
12 Centre for Research in Primary and Community Care, University of Hertfordshire, Hatfield, UK
13 Personal Social Services Research Unit, University of Manchester, Manchester, UK
14 Research Department of Clinical, Educational, and Health Psychology, University College London, London, UK
15 School of Healthcare Sciences, Cardiff University, Cardiff, UK
16 Norwich Medical School, University of East Anglia, Norwich, UK
17 Research Institute for the Care of Older People, University of Bath, Bath, UK
18 Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK
19 Faculty of Health and Social Care, University of Hull, Hull, UK
20 Institute of Mental Health, University of Nottingham, Nottingham, UK
21 Nuffield Department of Population Health, University of Oxford, Oxford, UK
22 School of Health & Community Studies, Leeds Beckett University, Leeds, UK
23 Collaboration for Leadership in Applied Health Research and Care South West Peninsula, University of Exeter, Exeter, UK
24 Wolfson Centre for Age-Related Diseases, King’s College London, London, UK
25 Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK
26 School of Psychology, University of Exeter, Exeter, UK
27 Centre for Research in Ageing and Cognitive Health, University of Exeter Medical School, Exeter, UK
28 Neuroscience Research Centre, St George’s, University of London, UK
29 School of Clinical Sciences, University of Bristol, Bristol, UK
30 Centre for Public Health, Queen’s University Belfast, Belfast, UK
31 School of Medicine, University of Southampton, Southampton, UK
32 Aston Research Centre for Healthy Ageing, Aston University, Birmingham, UK
33 Cicely Saunders Institute, King’s College London, London, UK
34 Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
35 Camden and Islington NHS Foundation Trust, London, UK
36 North Thames Collaboration for Leadership in Applied Health Research and Care, London, UK
* Corresponding author Email: G.livingston@ucl.ac.uk

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https://dx.doi.org/{{metadata.DOI}}

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