Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a tumour necrosis factor inhibitor: a systematic review and economic evaluation

Malottki, K; Barton, P; Tsourapas, A; Uthman, AO; Liu, Z; Routh, K; Connock, M; Jobanputra, P; Moore, D; Fry-Smith, A; Chen, Y-F

doi:10.3310/hta15140

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Study found rituximab and abatacept to be more effective compared with supportive care (including ongoing disease-modifying antirheumatic drugs) in rheumatoid arthritis after failure of a TNF inhibitor. Use of an alternative TNF inhibitor in this patient population may provide some benefit according to evidence from observational studies, but there remain uncertainties with regard to the magnitude of the benefit and its cost-effectiveness.

K Malottki, P Barton, A Tsourapas, AO Uthman, Z Liu, K Routh, M Connock, P Jobanputra, D Moore, A Fry-Smith & Y-F Chen.

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K Malottki, P Barton, A Tsourapas, AO Uthman, Z Liu, K Routh, M Connock, P Jobanputra, D Moore, A Fry-Smith, Y-F Chen ^*

West Midlands Health Technology Assessment Collaboration, University of Birmingham, Edgbaston, Birmingham, UK
^* Corresponding author Email:

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