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The introduction of regional citrate anticoagulation to intensive care units has not improved outcomes for patients and is likely to have substantially increased costs.

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Doug W Gould 1, James Doidge 1, M Zia Sadique 2, Mark Borthwick 3, Robert Hatch 4, Fergus J Caskey 5,6, Lui Forni 7,8, Robert F Lawrence 9, Clare MacEwen 3, Marlies Ostermann 10, Paul R Mouncey 1, David A Harrison 1, Kathryn M Rowan 1, J Duncan Young 4, Peter J Watkinson 4,*

1 Clinical Trials Unit, Intensive Care National Audit & Research Centre (ICNARC), London, UK
2 Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK
3 John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
4 Kadoorie Centre for Critical Care Research and Education, NIHR Biomedical Research Centre, Oxford, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
5 UK Renal Registry, Bristol, UK
6 Population Health Sciences, University of Bristol, Bristol, UK
7 Department of Clinical and Experimental Medicine, Faculty of Health Sciences, University of Surrey, Guildford, UK
8 Intensive Care Unit, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK
9 Patient representative, , Oxford, UK
10 Department of Intensive Care, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
* Corresponding author Email:

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