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This study showed that PET-CT is more accurate but more costly than DCE-CT in characterising solitary pulmonary nodules but found a combination of both improved the accuracy further.

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Fiona J Gilbert 1,*, Scott Harris 2, Kenneth A Miles 1,3, Jonathan R Weir-McCall 1, Nagmi R Qureshi 3, Robert C Rintoul 4,5, Sabina Dizdarevic 6,7, Lucy Pike 8, Donald Sinclair 8, Andrew Shah 9, Rosemary Eaton 9, Andrew Clegg 10, Valerio Benedetto 10, James E Hill 10, Andrew Cook 11,12, Dimitrios Tzelis 13, Luke Vale 13, Lucy Brindle 14, Jackie Madden 11,12, Kelly Cozens 11,12, Louisa A Little 11,12, Kathrin Eichhorst 11,12, Patricia Moate 11,12,, Chris McClement 11,12,, Charles Peebles 15, Anindo Banerjee 15, Sai Han 16, Fat Wui Poon 16, Ashley M Groves 17, Lutfi Kurban 18, Anthony J Frew 6,7,, Matthew E Callister 19, Philip Crosbie 20, Fergus V Gleeson 21,22, Kavitasagary Karunasaagarar 23, Osei Kankam 24, Steve George 11,12,

1 Department of Radiology, University of Cambridge School of Clinical Medicine, Biomedical Research Centre, University of Cambridge, Cambridge, UK
2 Public Health Sciences and Medical Statistics, University of Southampton, Southampton, UK
3 Department of Radiology, Royal Papworth Hospital, Cambridge, UK
4 Department of Thoracic Oncology, Royal Papworth Hospital, Cambridge, UK
5 Department of Oncology, University of Cambridge, Cambridge, UK
6 Departments of Imaging and Nuclear Medicine and Respiratory Medicine, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK
7 Brighton and Sussex Medical School, Brighton, UK
8 King’s College London and Guy’s and St Thomas’ PET Centre, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, UK
9 Radiation Protection Department, East and North Hertfordshire NHS Trust, Stevenage, UK
10 Faculty of Health and Wellbeing, University of Central Lancashire, Preston, UK
11 University Hospital Southampton NHS Foundation Trust, Southampton, UK
12 Southampton Clinical Trials Unit, University of Southampton, Southampton, UK
13 Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK
14 School of Health Sciences, University of Southampton, Southampton, UK
15 Department of Radiology and Respiratory Medicine, University Hospital Southampton NHS Foundation Trust, Southampton, UK
16 West of Scotland PET Centre, Gartnavel Hospital, Glasgow, UK
17 Institute of Nuclear Medicine, University College London, London, UK
18 Department of Radiology, Aberdeen Royal Hospitals NHS Trust, Aberdeen, UK
19 Department of Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK
20 North West Lung Centre, University Hospital of South Manchester, Manchester, UK
21 Department of Radiology, Churchill Hospital, Oxford, UK
22 University of Oxford, Oxford, UK
23 Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
24 Department of Thoracic Medicine, East Sussex Healthcare NHS Trust, Saint Leonards-on-Sea, UK
* Corresponding author Email:

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