Standard threshold laser versus subthreshold micropulse laser for adults with diabetic macular oedema: the DIAMONDS non-inferiority RCT

Lois, Noemi; Campbell, Christina; Waugh, Norman; Azuara-Blanco, Augusto; Maredza, Mandy; Mistry, Hema; McAuley, Danny; Acharya, Nachiketa; Aslam, Tariq M; Bailey, Clare; Chong, Victor; Downey, Louise; Eleftheriadis, Haralabos; Fatum, Samia; George, Sheena; Ghanchi, Faruque; Groppe, Markus; Hamilton, Robin; Menon, Geeta; Saad, Ahmed; Sivaprasad, Sobha; Shiew, Marianne; Steel, David H; Talks, James Stephen; Doherty, Paul; McDowell, Clíona; Clarke, Mike

doi:10.3310/SZKI2484

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Subthreshold micropulse laser for diabetic macular oedema with central retinal thickness less than 400µ was equivalent to standard threshold laser but required a slightly higher number of laser treatments.

Noemi Lois , Christina Campbell , Norman Waugh , Augusto Azuara-Blanco , Mandy Maredza , Hema Mistry , Danny McAuley , Nachiketa Acharya , Tariq M Aslam , Clare Bailey , Victor Chong , Louise Downey , Haralabos Eleftheriadis , Samia Fatum , Sheena George , Faruque Ghanchi , Markus Groppe , Robin Hamilton , Geeta Menon , Ahmed Saad , Sobha Sivaprasad , Marianne Shiew , David H Steel , James Stephen Talks , Paul Doherty , Clíona McDowell & Mike Clarke .

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Noemi Lois ^1,^*, Christina Campbell ², Norman Waugh ³, Augusto Azuara-Blanco ⁴, Mandy Maredza ³, Hema Mistry ⁵, Danny McAuley ^1,⁶, Nachiketa Acharya ⁷, Tariq M Aslam ^8,⁹, Clare Bailey ¹⁰, Victor Chong ¹¹, Louise Downey ¹², Haralabos Eleftheriadis ¹³, Samia Fatum ¹⁴, Sheena George ¹⁵, Faruque Ghanchi ¹⁶, Markus Groppe ¹⁷, Robin Hamilton ¹⁸, Geeta Menon ¹⁹, Ahmed Saad ^20,²¹, Sobha Sivaprasad ¹⁸, Marianne Shiew ²², David H Steel ^23,²⁴, James Stephen Talks ²⁵, Paul Doherty ², Clíona McDowell ², Mike Clarke ^2,⁴

¹ The Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, UK
² Northern Ireland Clinical Trials Unit (NICTU), Belfast, UK
³ Division of Health Sciences, University of Warwick, Coventry, UK
⁴ Centre for Public Health, Queens University, Belfast, UK
⁵ Warwick Clinical Trials Unit, University of Warwick, Coventry, UK
⁶ The Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK
⁷ Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
⁸ The Manchester Academic Health Science Centre, Manchester Royal Eye Hospital, Manchester, UK
⁹ Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
¹⁰ Bristol Eye Hospital, Bristol, UK
¹¹ Royal Free Hospital NHS Foundation Trust, London, UK
¹² Hull and East Yorkshire Hospital, Hull and East Yorkshire NHS Trust, Hull, UK
¹³ King’s College Hospital NHS Foundation Trust, London, UK
¹⁴ John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
¹⁵ Hillingdon Hospitals NHS Foundation Trust, London, UK
¹⁶ Bradford Teaching Hospitals NHS Trust, Bradford, UK
¹⁷ Stoke Mandeville Hospital, Buckinghamshire NHS Trust, Aylesbury, UK
¹⁸ National Institute for Health and Care Research Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK
¹⁹ Frimley Park Hospital NHS Foundation Trust, Camberley, UK
²⁰ James Cook University Hospital, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK
²¹ Zagazig University, Zagazig, Egypt
²² Hinchingbrooke Hospital North West Anglia NHS Trust, Huntingdon, UK
²³ Sunderland Eye Infirmary, Sunderland, UK
²⁴ Bioscience Institute, Newcastle University, Newcastle upon Tyne, UK
²⁵ Newcastle Eye Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
^* Corresponding author Email: n.lois@qub.ac.uk

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