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This trial showed that plasma exchange did not delay onset of end-stage renal disease or death and reduced oral steroid dosing was no less effective than the standard dose.

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David Jayne 1,*, Michael Walsh 2, Peter A Merkel 3, Chen Au Peh 4, Wladimir Szpirt 5, Xavier Puéchal 6, Shouichi Fujimoto 7, Carmel Hawley 8, Nader Khalidi 9, Rachel Jones 10, Oliver Flossmann 11, Ron Wald 12, Louis Girard 13, Adeera Levin 14, Gina Gregorini 15, Lorraine Harper 16, William Clark 17, Christian Pagnoux 18, Ulrich Specks 19, Lucy Smyth 20, Toshiko Ito-Ihara 21, Janak de Zoysa 22, Biljana Brezina 10, Andrea Mazzetti 23, Carol A McAlear 3, Donna Reidlinger 24, Samir Mehta 25, Natalie Ives 25, Elizabeth A Brettell 25, Hugh Jarrett 25, Keith Wheatley 26, Elizabeth Broadhurst 1, Alina Casian 1, Charles D Pusey 27

1 Department of Medicine, University of Cambridge, Cambridge, UK
2 Department of Nephrology, McMaster University, Hamilton, ON, Canada
3 Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA
4 Royal Adelaide Hospital, Adelaide, SA, Australia
5 Department of Nephrology, Rigshospitalet, Copenhagen, Denmark
6 National Referral Centre for Rare Systemic Autoimmune Diseases, Cochin Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France
7 Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
8 Department of Nephrology, The University of Queensland, Brisbane, QLD, Australia
9 Department of Rheumatology, McMaster University, Hamilton, ON, Canada
10 Renal Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
11 Renal Unit, Royal Berkshire Hospital, Reading, UK
12 Department of Rheumatology, St Michael’s Hospital, Toronto, ON, Canada
13 Department of Nephrology, University of Calgary, Calgary, AB, Canada
14 Department of Nephrology, St Paul’s Hospital, Vancouver, BC, Canada
15 Department of Nephrology, Azienda Ospedaliera Spedali Civili di Brescia, Brescia, Italy
16 Department of Nephrology, University of Birmingham, Birmingham, UK
17 Department of Nephrology, University of Western Ontario, London, ON, Canada
18 Department of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada
19 Department of Pulmonary Medicine, Mayo Clinic, Rochester, MN, USA
20 Department of Nephrology, The Royal Devon and Exeter Hospital, Exeter, UK
21 Clinical and Translational Research Centre, Kyoto Prefecture University of Medicine, Kyoto, Japan
22 Department of Nephrology, North Shore Hospital, Auckland, New Zealand
23 The Research Institute, St Joseph’s Healthcare, Hamilton, ON, Canada
24 Australasian Kidney Trials Network, The University of Queensland, Brisbane, QLD, Australia
25 Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK
26 Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK
27 Department of Nephrology, Imperial College London, London, UK
* Corresponding author Email:

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