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1 Bristol Trials Centre, University of Bristol, Bristol, UK
2 Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK
3 Department of Cardiology, Bristol Heart Institute, Bristol, UK
4 National Institute for Health Research Biomedical Research Centre, Department of Population Health Sciences, University of Bristol, Bristol, UK
5 National Institute for Health Research Applied Research Collaboration West (NIHR ARC West), Bristol, UK
6 Bristol Medical School, University of Bristol, Bristol, UK
7 Norwich Medical School, University of East Anglia, Norwich, UK
8 Institute of Applied Health Research, University of Birmingham, Birmingham, UK
9 Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK
10 Health and Social Sciences, University of the West of England, Bristol, Bristol, UK
* Corresponding author Email: maria.pufulete@bristol.ac.uk
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