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Paul Little, Nick A Francis, Beth Stuart, Gilly O’Reilly, Natalie Thompson, Taeko Becque, Alastair D Hay, Kay Wang, Michael Sharland, Anthony Harnden, Guiqing Yao, James Raftery, Shihua Zhu, Joseph Little, Charlotte Hookham, Kate Rowley, Joanne Euden, Kim Harman, Samuel Coenen, Robert C Read, Catherine Woods, Christopher C Butler, Saul N Faust, Geraldine Leydon, Mandy Wan, Kerenza Hood, Jane Whitehurst, Samantha Richards-Hall, Peter Smith, Michael Thomas, Michael Moore & Theo Verheij.

Paul Little ^1,*, Nick A Francis ¹, Beth Stuart ¹, Gilly O’Reilly ¹, Natalie Thompson ¹, Taeko Becque ¹, Alastair D Hay ², Kay Wang ³, Michael Sharland ⁴, Anthony Harnden ³, Guiqing Yao ⁵, James Raftery ¹, Shihua Zhu ¹, Joseph Little ¹, Charlotte Hookham ¹, Kate Rowley ², Joanne Euden ⁶, Kim Harman ¹, Samuel Coenen ⁷, Robert C Read ^8,9, Catherine Woods ¹, Christopher C Butler ³, Saul N Faust ^8,9, Geraldine Leydon ¹, Mandy Wan ¹⁰, Kerenza Hood ⁶, Jane Whitehurst ¹¹, Samantha Richards-Hall ¹², Peter Smith ¹³, Michael Thomas ¹, Michael Moore ¹, Theo Verheij ^1,14

¹ Primary Care Population Sciences and Medical Education Unit, University of Southampton, Southampton, UK
² Centre for Academic Primary Care, Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK
³ Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
⁴ Institute of Infection and Immunity, St George’s University, London, UK
⁵ Biostatistics Research Group, Department of Health Sciences, College of Life Sciences, University of Leicester, Leicester, UK
⁶ Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK
⁷ Department of Family Medicine & Population Health and Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium
⁸ National Institute for Health and Care Research (NIHR) Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
⁹ Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK
¹⁰ Evelina Pharmacy, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
¹¹ National Institute for Health and Care Research (NIHR) Applied Research Collaboration West Midlands, Coventry, UK
¹² Southampton Primary Care Research Centre, Primary Care Population Sciences and Medical Education Unit, University of Southampton, Southampton, UK
¹³ Southampton Statistical Sciences Research Institute, University of Southampton, Southampton, UK
¹⁴ Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, the Netherlands
^* Corresponding author Email: p.little@soton.ac.uk