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Losartan administered over 12 months did not alter brain atrophy in Alzheimer's disease.

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Patrick G Kehoe 1,*, Nicholas Turner 2, Beth Howden 2, Lina Jarutyt 3, Shona L Clegg 4, Ian B Malone 4, Josephine Barnes 4, Casper Nielsen 4, Carole H Sudre 4,5, Aileen Wilson 6, N Jade Thai 6, Peter S Blair 2, Elizabeth J Coulthard 3, J Athene Lane 2, Peter Passmore 7, Jodi Taylor 2, Henk-Jan Mutsaerts 8,9, David L Thomas 10, Nick C Fox 4,10, Ian Wilkinson 11, Yoav Ben-Shlomo 2

1 Dementia Research Group, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
2 Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
3 ReMemBr Group, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
4 Dementia Research Centre (DRC), Institute of Neurology, University College London, London, UK
5 School of Biomedical Engineering and Imaging Sciences, King’s College London, London, UK
6 Clinical Research Imaging Centre, University of Bristol, Bristol, UK
7 Institute of Clinical Sciences, Queen’s University Belfast, Royal Victoria Hospital, Belfast, UK
8 Academic Medical Centre, Amsterdam, the Netherlands
9 Ghent University Hospital, Ghent, Belgium
10 Leonard Wolfson Experimental Neurology Centre, UCL Institute of Neurology, London, UK
11 Clinical Pharmacology Unit, School of Clinical Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
* Corresponding author Email: Patrick.Kehoe@bristol.ac.uk

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