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The trial was stopped early because of profound respiratory adverse effects, without evidence of analgesic benefit for procedural pain, from the administration of oral morphine to non-ventilated premature infants.

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Vaneesha Monk 1,*,, Fiona Moultrie 1,, Caroline Hartley 1, Amy Hoskin 1, Gabrielle Green 1, Jennifer L Bell 2, Caz Stokes 3, Ed Juszczak 2, Jane Norman 4, Richard Rogers 5, Chetan Patel 6, Eleri Adams 7,, Rebeccah Slater 1,

1 Department of Paediatrics, University of Oxford, Oxford, UK
2 National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
3 Support for the Sick Newborn and their Parents, Oxford, UK
4 Tommy’s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
5 Department of Anaesthetics, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
6 Department of Ophthalmology, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
7 Newborn Care Unit, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
* Corresponding author Email: vaneesha.monk@paediatrics.ox.ac.uk

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