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Adding levosimendan to standard care for patients with septic shock did not reduce organ dysfunction, and may have increased risk of serious adverse events.

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Anthony C Gordon 1,*, Shalini Santhakumaran 2, Farah Al-Beidh 1,2, Robert M L Orme 3, Gavin D Perkins 4, Mervyn Singer 5, Daniel F McAuley 6,7, Alexina J Mason 8, Josie K Ward 1, Kieran P O’Dea 1, Timothy Felton 9, Mary Cross 2, Janis Best-Lane 1,2, Jonas Lexow 1,2, Ashley Campbell 1,2, Deborah Ashby 2

1 Section of Anaesthetics, Pain Medicine and Intensive Care Medicine, Department of Surgery and Cancer, Imperial College London and Imperial College Healthcare NHS Trust, London, UK
2 Imperial Clinical Trials Unit, Imperial College London, London, UK
3 Department of Critical Care, Cheltenham General Hospital, Cheltenham, UK
4 Warwick Clinical Trials Unit, University of Warwick and Heart of England NHS Foundation Trust, Coventry, UK
5 Bloomsbury Institute for Intensive Care Medicine, Division of Medicine, University College London, London, UK
6 Centre for Experimental Medicine, Queen’s University Belfast, Belfast, UK
7 Regional Intensive Care Unit, The Royal Hospitals, Belfast, UK
8 Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK
9 Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK
* Corresponding author Email: anthony.gordon@imperial.ac.uk

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