Leucine and perindopril to improve physical performance in people over 70 years with sarcopenia: the LACE factorial RCT

Witham, Miles D; Adamson, Simon; Avenell, Alison; Band, Margaret M; Bashir, Tufail; Donnan, Peter T; George, Jacob; Hapca, Adrian; Hume, Cheryl; Kemp, Paul; McKenzie, Emma; Pilvinyte, Kristina; Rossios, Christos; Smith, Karen; Struthers, Allan D; Sumukadas, Deepa

doi:10.3310/LLBX6901

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This trial did not find that either perindopril once daily or leucine thrice daily improved physical performance at 12 months.

Miles D Witham , Simon Adamson , Alison Avenell , Margaret M Band , Tufail Bashir , Peter T Donnan , Jacob George , Adrian Hapca , Cheryl Hume , Paul Kemp , Emma McKenzie , Kristina Pilvinyte , Christos Rossios , Karen Smith , Allan D Struthers & Deepa Sumukadas .

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Miles D Witham ^1,^2,^*, Simon Adamson ³, Alison Avenell ⁴, Margaret M Band ³, Tufail Bashir ⁵, Peter T Donnan ³, Jacob George ², Adrian Hapca ³, Cheryl Hume ³, Paul Kemp ⁵, Emma McKenzie ³, Kristina Pilvinyte ³, Christos Rossios ⁵, Karen Smith ³, Allan D Struthers ², Deepa Sumukadas ⁶

¹ AGE Research Group, NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne Hospitals Trust, Newcastle upon Tyne, UK
² Molecular and Clinical Medicine, University of Dundee, Dundee, UK
³ Tayside Clinical Trials Unit, University of Dundee, Dundee, UK
⁴ Health Services Research Unit, University of Aberdeen, Aberdeen, UK
⁵ Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, London, UK
⁶ Department of Medicine for the Elderly, NHS Tayside, Dundee, UK
^* Corresponding author Email: Miles.Witham@newcastle.ac.uk

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