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This trial did not find that either perindopril once daily or leucine thrice daily improved physical performance at 12 months.

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Miles D Witham 1,2,*, Simon Adamson 3, Alison Avenell 4, Margaret M Band 3, Tufail Bashir 5, Peter T Donnan 3, Jacob George 2, Adrian Hapca 3, Cheryl Hume 3, Paul Kemp 5, Emma McKenzie 3, Kristina Pilvinyte 3, Christos Rossios 5, Karen Smith 3, Allan D Struthers 2, Deepa Sumukadas 6

1 AGE Research Group, NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne Hospitals Trust, Newcastle upon Tyne, UK
2 Molecular and Clinical Medicine, University of Dundee, Dundee, UK
3 Tayside Clinical Trials Unit, University of Dundee, Dundee, UK
4 Health Services Research Unit, University of Aberdeen, Aberdeen, UK
5 Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, London, UK
6 Department of Medicine for the Elderly, NHS Tayside, Dundee, UK
* Corresponding author Email:

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