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Adaptive stratified medicine studies are feasible in common cancers but this increases complexity and reduces the proportion of patients eligible for randomisation.

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Louise C Brown 1, David Fisher 1, Richard Adams 2,3, Jenny Seligmann 4, Matthew Seymour 4, Richard Kaplan 1, Susan D Richman 4, Philip Quirke 4, Rachel Butler 5, Helen Roberts 2,3, Janet Graham 6,7, Richard H Wilson 6,7, Timothy S Maughan 8,*

1 Medical Research Council Clinical Trials Unit, University College London, London, UK
2 Centre for Trials Research, Cardiff University, Cardiff, UK
3 Oncology Department, Velindre Cancer Centre, Velindre University NHS Trust, Cardiff, UK
4 Leeds Institute of Medical Research, University of Leeds, Leeds, UK
5 Bristol Genetics Laboratory, Bristol, UK
6 Beatson West of Scotland Cancer Centre, Glasgow, UK
7 Institute of Cancer Sciences, University of Glasgow, Glasgow, UK
8 Department of Oncology, University of Oxford, Oxford, UK
* Corresponding author Email:

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