Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients:the R4-RA RCT

Humby, Frances; Durez, Patrick; Buch, Maya H; Lewis, Myles J; Bombardieri, Michele; John, Christopher; Rizvi, Hasan; Warren, Louise; Peel, Joanna; Fossati-Jimack, Liliane; Hands, Rebecca E; Giorli, Giovanni; Rivellese, Felice; Cañete, Juan D; Taylor, Peter C; Sasieni, Peter; Fonseca, João E; Choy, Ernest; Pitzalis, Costantino

doi:10.3310/GOPL1729

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This trial did not show that tocilizumab was more effective than rituximab in patients with a B-cell-poor pathotype in the primary analysis; however, superiority was shown in most supplementary and secondary analyses using a molecular classification.

Frances Humby , Patrick Durez , Maya H Buch , Myles J Lewis , Michele Bombardieri , Christopher John , Hasan Rizvi , Louise Warren , Joanna Peel , Liliane Fossati-Jimack , Rebecca E Hands , Giovanni Giorli , Felice Rivellese , Juan D Cañete , Peter C Taylor , Peter Sasieni , João E Fonseca , Ernest Choy & Costantino Pitzalis .

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Frances Humby ¹, Patrick Durez ², Maya H Buch ³, Myles J Lewis ¹, Michele Bombardieri ¹, Christopher John ¹, Hasan Rizvi ⁴, Louise Warren ¹, Joanna Peel ¹, Liliane Fossati-Jimack ¹, Rebecca E Hands ¹, Giovanni Giorli ¹, Felice Rivellese ¹, Juan D Cañete ⁵, Peter C Taylor ⁶, Peter Sasieni ⁷, João E Fonseca ⁸, Ernest Choy ⁹, Costantino Pitzalis ^1,^*

¹ Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, UK
² Institute of Experimental and Clinical Research, Université Catholique de Louvain, Louvain, Belgium
³ Clinical Trials Research Unit, University of Leeds, Leeds, UK
⁴ Blizard Institute, Barts Health NHS Trust, London, UK
⁵ Arthritis Unit, L’Institut d’Investigacions Biomèdiques, Barcelona, Spain
⁶ Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
⁷ King’s Clinical Trial Unit, King’s College London, London, UK
⁸ Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal
⁹ Section of Rheumatology, Cardiff University School of Medicine, Cardiff University, Cardiff, UK
^* Corresponding author Email: c.pitzalis@qmul.ac.uk

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