Immediate oral versus immediate topical versus delayed oral antibiotics for children with acute otitis media with discharge: the REST three-arm non-inferiority electronic platform-supported RCT

Hay, Alastair D; Moore, Michael V; Taylor, Jodi; Turner, Nicholas; Noble, Sian; Cabral, Christie; Horwood, Jeremy; Prasad, Vibhore; Curtis, Kathryn; Delaney, Brendan; Damoiseaux, Roger; Domínguez, Jesús; Tapuria, Archana; Harris, Sue; Little, Paul; Lovering, Andrew; Morris, Richard; Rowley, Kate; Sadoo, Annie; Schilder, Anne; Venekamp, Roderick; Wilkes, Scott; Curcin, Vasa

doi:10.3310/hta25670

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Evolving IT security and electronic record requirements hampered platform function resulting in poor recruitment and early trial closure, and the authors make recommendations about electronic platforms for primary care research.

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Alastair D Hay ^1,^†,^*, Michael V Moore ^2,^†, Jodi Taylor ³, Nicholas Turner ³, Sian Noble ³, Christie Cabral ¹, Jeremy Horwood ¹, Vibhore Prasad ⁴, Kathryn Curtis ³, Brendan Delaney ⁵, Roger Damoiseaux ⁶, Jesús Domínguez ⁴, Archana Tapuria ⁴, Sue Harris ³, Paul Little ², Andrew Lovering ⁷, Richard Morris ³, Kate Rowley ³, Annie Sadoo ³, Anne Schilder ⁸, Roderick Venekamp ⁶, Scott Wilkes ⁹, Vasa Curcin ⁴

¹ Centre for Academic Primary Care, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
² Primary Care and Population Sciences, University of Southampton, Southampton, UK
³ Bristol Randomised Trials Collaboration, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
⁴ School of Population Health and Environmental Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK
⁵ Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
⁶ Julius Center for Health Sciences and Primary Care & Department of Otorhinolaryngology, UMC Utrecht, Utrecht, the Netherlands
⁷ Department of Medical Microbiology, North Bristol NHS Trust, Bristol, UK
⁸ Ear Institute, University College London, London, UK
⁹ School of Medicine, University of Sunderland, Sunderland, UK
^* Corresponding author Email: alastair.hay@bristol.ac.uk

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