Cognitive behavioural therapy compared with standardised medical care for adults with dissociative non-epileptic seizures: the CODES RCT

Goldstein, Laura H; Robinson, Emily J; Pilecka, Izabela; Perdue, Iain; Mosweu, Iris; Read, Julie; Jordan, Harriet; Wilkinson, Matthew; Rawlings, Gregg; Feehan, Sarah J; Callaghan, Hannah; Day, Elana; Purnell, James; Baldellou Lopez, Maria; Brockington, Alice; Burness, Christine; Poole, Norman A; Eastwood, Carole; Moore, Michele; Mellers, John DC; Stone, Jon; Carson, Alan; Medford, Nick; Reuber, Markus; McCrone, Paul; Murray, Joanna; Richardson, Mark P; Landau, Sabine; Chalder, Trudie

doi:10.3310/hta25430

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This trial showed that there was no significant benefit of adjunctive dissociative-specific CBT in reducing the frequency of dissociative (non-epileptic) seizures at 12 months.

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Laura H Goldstein ^1,^*, Emily J Robinson ^2,³, Izabela Pilecka ¹, Iain Perdue ¹, Iris Mosweu ⁴, Julie Read ¹, Harriet Jordan ¹, Matthew Wilkinson ^5,⁶, Gregg Rawlings ⁷, Sarah J Feehan ¹, Hannah Callaghan ⁸, Elana Day ¹, James Purnell ¹, Maria Baldellou Lopez ¹, Alice Brockington ⁹, Christine Burness ¹⁰, Norman A Poole ¹¹, Carole Eastwood ¹, Michele Moore ¹², John DC Mellers ⁶, Jon Stone ⁸, Alan Carson ⁸, Nick Medford ⁶, Markus Reuber ¹³, Paul McCrone ⁴, Joanna Murray ¹⁴, Mark P Richardson ¹⁵, Sabine Landau ^2,^†, Trudie Chalder ^16,^†

¹ Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
² Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
³ School of Population Health and Environmental Sciences, King’s College London, London, UK
⁴ King’s Health Economics, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK
⁵ Canterbury Christ Church University, Salamons Institute for Applied Psychology, Tunbridge Wells, UK
⁶ South London and Maudsley NHS Foundation Trust, London, UK
⁷ School of Clinical Psychology, University of Sheffield, Sheffield, UK
⁸ Department of Clinical Neuroscience, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
⁹ Department of Neurology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
¹⁰ The Walton Centre NHS Trust, Liverpool, UK
¹¹ Department of Neuropsychiatry, St George’s Hospital, South West London and St George’s NHS Mental Health NHS Trust, London, UK
¹² Centre for Social Justice and Global Responsibility, School of Law and Social Sciences, London South Bank University, London, UK
¹³ Academic Neurology Unit, Royal Hallamshire Hospital, University of Sheffield, Sheffield, UK
¹⁴ Department of Health Services & Population Research, Institute of Psychiatry,Psychology and Neuroscience, King’s College London, London, UK
¹⁵ Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
¹⁶ Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
^* Corresponding author Email: laura.goldstein@kcl.ac.uk

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