Adrenaline to improve survival in out-of-hospital cardiac arrest: the PARAMEDIC2 RCT

Perkins, Gavin D; Ji, Chen; Achana, Felix; Black, John JM; Charlton, Karl; Crawford, James; de Paeztron, Adam; Deakin, Charles; Docherty, Mark; Finn, Judith; Fothergill, Rachael T; Gates, Simon; Gunson, Imogen; Han, Kyee; Hennings, Susie; Horton, Jessica; Khan, Kamran; Lamb, Sarah; Long, John; Miller, Joshua; Moore, Fionna; Nolan, Jerry; O’Shea, Lyndsey; Petrou, Stavros; Pocock, Helen; Quinn, Tom; Rees, Nigel; Regan, Scott; Rosser, Andy; Scomparin, Charlotte; Slowther, Anne; Lall, Ranjit

doi:10.3310/hta25250

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This trial found that 3.2% of people treated with adrenaline following out-of-hospital cardiac arrest survived to 30 days, compared with 2.4% of people receiving placebo.

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Gavin D Perkins ^1,^2,^*, Chen Ji ¹, Felix Achana ¹, John JM Black ³, Karl Charlton ⁴, James Crawford ¹, Adam de Paeztron ¹, Charles Deakin ⁵, Mark Docherty ⁶, Judith Finn ⁷, Rachael T Fothergill ⁸, Simon Gates ⁹, Imogen Gunson ⁶, Kyee Han ⁴, Susie Hennings ¹, Jessica Horton ¹, Kamran Khan ¹, Sarah Lamb ¹, John Long ¹⁰, Joshua Miller ⁶, Fionna Moore ¹¹, Jerry Nolan ^1,¹², Lyndsey O’Shea ¹³, Stavros Petrou ¹, Helen Pocock ³, Tom Quinn ¹⁴, Nigel Rees ¹³, Scott Regan ¹, Andy Rosser ⁶, Charlotte Scomparin ¹, Anne Slowther ¹, Ranjit Lall ¹

¹ Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
² Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
³ South Central Ambulance Service NHS Foundation Trust, Bicester, UK
⁴ North East Ambulance Service NHS Foundation Trust, Newcastle upon Tyne, UK
⁵ Southampton University Hospital, Southampton, UK
⁶ West Midlands Ambulance Service University NHS Foundation Trust, Brierley Hill, UK
⁷ Prehospital, Resuscitation and Emergency Care Research Unit (PRECRU), Curtin University, Perth, WA, Australia
⁸ London Ambulance Service NHS Trust, London, UK
⁹ Cancer Research Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, UK
¹⁰ Patient and Public Involvement Representative, Warwick, UK
¹¹ South East Coast Ambulance Service NHS Foundation Trust, Crawley, UK
¹² Royal United Hospitals Bath NHS Foundation Trust, Bath, UK
¹³ Welsh Ambulance Service NHS Trust, St Asaph, UK
¹⁴ Emergency, Cardiovascular and Critical Care Research Group, Faculty of Health, Social Care and Education, Kingston University London and St George’s, University of London, London, UK
^* Corresponding author Email: G.D.Perkins@warwick.ac.uk

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