Developing a serocorrelate of protection against invasive group B streptococcus disease in pregnant women: a feasibility study

Carreras-Abad, Clara; Cochet, Madeleine; Hall, Tom; Ramkhelawon, Laxmee; Khalil, Asma; Peregrine, Elisabeth; Vinayakarao, Latha; Sivarajan, Sharmila; Hamid, Rosol; Planche, Tim; Sheridan, Elizabeth; Winchester, Stephen; Plumb, Jane; Djennad, Abdelmajid; Andrews, Nick; Le Doare, Kirsty; Heath, Paul

doi:10.3310/hta23670

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This study assessed key operational aspects of study design needed to determine the correlates of protection against invasive group B streptococcus and confirmed that a full study is feasible.

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Clara Carreras-Abad ¹, Madeleine Cochet ¹, Tom Hall ¹, Laxmee Ramkhelawon ¹, Asma Khalil ², Elisabeth Peregrine ³, Latha Vinayakarao ⁴, Sharmila Sivarajan ⁵, Rosol Hamid ⁶, Tim Planche ⁷, Elizabeth Sheridan ⁸, Stephen Winchester ⁹, Jane Plumb ¹⁰, Abdelmajid Djennad ¹¹, Nick Andrews ¹¹, Kirsty Le Doare ^1,^*, Paul Heath ¹

¹ Paediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, St George’s, University of London, London, UK
² Department of Obstetrics and Gynaecology, St George’s University Hospitals NHS Foundation Trust, London, UK
³ Department of Obstetrics and Gynaecology, Kingston Hospital NHS Foundation Trust, London, UK
⁴ Department of Obstetrics and Gynaecology, Poole Hospital NHS Foundation Trust, Poole, UK
⁵ Department of Obstetrics and Gynaecology, Surrey and Sussex Healthcare NHS Trust, Redhill, UK
⁶ Department of Obstetrics and Gynaecology, Croydon Health Services NHS Trust, Croydon, UK
⁷ Microbiology Department, St George’s University Hospitals NHS Foundation Trust, London, UK
⁸ Microbiology Department, Poole Hospital NHS Foundation Trust, Poole, UK
⁹ Microbiology Department, Surrey and Sussex Healthcare NHS Trust, Redhill, UK
¹⁰ Group B Strep Support Group, Haywards Heath, UK
¹¹ Statistics, Modelling and Economics Department, National Infection Service, Public Health England, London, UK
^* Corresponding author Email: k.ledoare@nhs.net

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