Uterotonic drugs to prevent postpartum haemorrhage: a network meta-analysis

Gallos, Ioannis; Williams, Helen; Price, Malcolm; Pickering, Karen; Merriel, Abi; Tobias, Aurelio; Lissauer, David; Gee, Harry; Tunçalp, Özge; Gyte, Gillian; Moorthy, Vidhya; Roberts, Tracy; Deeks, Jonathan; Hofmeyr, Justus; Gülmezoglu, Metin; Coomarasamy, Arri

doi:10.3310/hta23090

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Ergometrine plus oxytocin, misoprostol plus oxytocin and carbetocin were more effective for preventing postpartum haemorrhage than the standard oxytocin, but ergometrine plus oxytocin and misoprostol plus oxytocin caused significant side effects.

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Ioannis Gallos ^1,^*, Helen Williams ¹, Malcolm Price ², Karen Pickering ², Abi Merriel ¹, Aurelio Tobias ¹, David Lissauer ¹, Harry Gee ¹, Özge Tunçalp ³, Gillian Gyte ^4,⁵, Vidhya Moorthy ¹, Tracy Roberts ², Jonathan Deeks ², Justus Hofmeyr ⁶, Metin Gülmezoglu ³, Arri Coomarasamy ¹

¹ Tommy’s National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
² Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
³ Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
⁴ Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Centre for Women’s Health Research, Liverpool Women’s NHS Foundation Trust, Liverpool, UK
⁵ National Childbirth Trust, London, UK
⁶ Effective Care Research Unit, University of the Witwatersrand/Fort Hare, Eastern Cape Department of Health, East London, South Africa
^* Corresponding author Email: i.d.gallos@bham.ac.uk

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