Different temperature thresholds for antipyretic intervention in critically ill children with fever due to infection: the FEVER feasibility RCT

Peters, Mark J; Khan, Imran; Woolfall, Kerry; Deja, Elizabeth; Mouncey, Paul R; Wulff, Jerome; Mason, Alexina; Agbeko, Rachel; Draper, Elizabeth S; Fenn, Blaise; Gould, Doug W; Koelewyn, Abby; Klein, Nigel; Mackerness, Christine; Martin, Sian; O’Neill, Lauran; Ramnarayan, Padmanabhan; Tibby, Shane; Tume, Lyvonne; Watkins, Jason; Thorburn, Kent; Wellman, Paul; Harrison, David A; Rowan, Kathryn M

doi:10.3310/hta23050

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This study identified barriers to delivering a full trial, including acceptability of the permissive temperature threshold, and provides insight into how these barriers may be overcome.

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Mark J Peters ^1,^*, Imran Khan ², Kerry Woolfall ³, Elizabeth Deja ³, Paul R Mouncey ², Jerome Wulff ², Alexina Mason ², Rachel Agbeko ⁴, Elizabeth S Draper ⁵, Blaise Fenn ⁶, Doug W Gould ², Abby Koelewyn ², Nigel Klein ⁷, Christine Mackerness ⁴, Sian Martin ², Lauran O’Neill ¹, Padmanabhan Ramnarayan ⁸, Shane Tibby ⁹, Lyvonne Tume ¹⁰, Jason Watkins ⁶, Kent Thorburn ¹¹, Paul Wellman ⁹, David A Harrison ², Kathryn M Rowan ²

¹ Respiratory, Critical Care and Anaesthesia Unit, University College London Great Ormond Street Institute of Child Health, London, UK
² Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, UK
³ Department of Psychological Sciences, North West Hub for Trials Methodology, University of Liverpool, Liverpool, UK
⁴ Paediatric Intensive Care Unit, Great North Children’s Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
⁵ Department of Health Sciences, University of Leicester, Leicester, UK
⁶ Patient/Parent Representative, London, UK
⁷ Institute of Child Health, University College London, London, UK
⁸ Children’s Acute Transport Service, Great Ormond Street Hospital, London, UK
⁹ Evelina London Children’s Hospital, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
¹⁰ Faculty of Health and Applied Sciences, University of the West of England, Bristol, UK
¹¹ Alder Hey Children’s NHS Foundation Trust, Liverpool, UK
^* Corresponding author Email: mark.peters@ucl.ac.uk

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