Does progesterone prophylaxis to prevent preterm labour improve outcome? A randomised double-blind placebo-controlled trial (OPPTIMUM)

Norman, Jane E; Marlow, Neil; Messow, Claudia-Martina; Shennan, Andrew; Bennett, Philip R; Thornton, Steven; Robson, Stephen C; McConnachie, Alex; Petrou, Stavros; Sebire, Neil J; Lavender, Tina; Whyte, Sonia; Norrie, John

doi:10.3310/hta22350

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Progesterone had no significant beneficial or harmful effects on the primary obstetric, neonatal or childhood outcomes in women at high risk of preterm birth.

Jane E Norman
[Image - ORCID logo], Neil Marlow, Claudia-Martina Messow
[Image - ORCID logo], Andrew Shennan
[Image - ORCID logo], Philip R Bennett
[Image - ORCID logo], Steven Thornton
[Image - ORCID logo], Stephen C Robson
[Image - ORCID logo], Alex McConnachie
[Image - ORCID logo], Stavros Petrou
[Image - ORCID logo], Neil J Sebire
[Image - ORCID logo], Tina Lavender
[Image - ORCID logo], Sonia Whyte
[Image - ORCID logo] & John Norrie
[Image - ORCID logo].

Detailed Author information
Detailed Author information

Jane E Norman ^1,^*, Neil Marlow ², Claudia-Martina Messow ³, Andrew Shennan ⁴, Philip R Bennett ⁵, Steven Thornton ⁶, Stephen C Robson ⁷, Alex McConnachie ³, Stavros Petrou ⁸, Neil J Sebire ², Tina Lavender ⁹, Sonia Whyte ¹, John Norrie ¹⁰,

¹ Tommy’s Centre for Maternal and Fetal Health, MRC Centre for Maternal and Fetal Health, University of Edinburgh, Edinburgh, UK
² Institute of Women’s Health, University College London, London, UK
³ Robertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
⁴ Women’s Health Academic Centre, King’s College London, London, UK
⁵ Obstetrics and Gynaecology, Department of Surgery and Cancer, Imperial College London, London, UK
⁶ Obstetrics and Gynaecology (Barts), Queen Mary University of London, London, UK
⁷ The Medical School, University of Newcastle, Newcastle, UK
⁸ Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK
⁹ School of Nursing, University of Manchester, Manchester, UK
¹⁰ Centre for Healthcare Randomised Trials, Health Services Research Unit, University of Aberdeen, Aberdeen, UK
^* Corresponding author Email: jane.norman@ed.ac.uk

Funding: {{metadata.Funding}}

{{metadata.Journal}} Volume: {{metadata.Volume}}, Issue: {{metadata.Issue}}, Published in {{metadata.PublicationDate | date:'MMMM yyyy'}}

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