Aerobic and strength training exercise programme for cognitive impairment in people with mild to moderate dementia: the DAPA RCT

Lamb, Sarah E; Mistry, Dipesh; Alleyne, Sharisse; Atherton, Nicky; Brown, Deborah; Copsey, Bethan; Dosanjh, Sukhdeep; Finnegan, Susanne; Fordham, Beth; Griffiths, Frances; Hennings, Susie; Khan, Iftekhar; Khan, Kamran; Lall, Ranjit; Lyle, Samantha; Nichols, Vivien; Petrou, Stavros; Zeh, Peter; Sheehan, Bart

doi:10.3310/hta22280

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A structured exercise programme, while well tolerated and enjoyed, did not produce any clinically meaningful benefit in cognitive function for people with dementia, and a slight worsening was observed.

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Sarah E Lamb ^1,^2,^3,^*, Dipesh Mistry ², Sharisse Alleyne ², Nicky Atherton ², Deborah Brown ³, Bethan Copsey ^1,³, Sukhdeep Dosanjh ², Susanne Finnegan ², Beth Fordham ³, Frances Griffiths ², Susie Hennings ², Iftekhar Khan ², Kamran Khan ², Ranjit Lall ², Samantha Lyle ³, Vivien Nichols ², Stavros Petrou ², Peter Zeh ², Bart Sheehan ⁴

¹ Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
² Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
³ Centre for Rehabilitation Research In Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
⁴ Oxford University Hospitals NHS Foundation Trust, Oxford, UK
^* Corresponding author Email: sarah.lamb@ndorms.ox.ac.uk

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