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Extended Research Article
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The trial did not meet the criteria for progression, with 17% of eligible patients randomised, and a full trial is not presently possible.

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Naeem Soomro
[Image - ORCID logo], Jan Lecouturier
[Image - ORCID logo], Deborah D Stocken
[Image - ORCID logo], Jing Shen
[Image - ORCID logo], Ann Marie Hynes
[Image - ORCID logo], Holly F Ainsworth
[Image - ORCID logo], David Breen
[Image - ORCID logo], Grenville Oades
[Image - ORCID logo], David Rix
[Image - ORCID logo] & Michael Aitchison
[Image - ORCID logo].


Naeem Soomro 1,*, Jan Lecouturier 2, Deborah D Stocken 2,3, Jing Shen 2, Ann Marie Hynes 3, Holly F Ainsworth 2, David Breen 4, Grenville Oades 5, David Rix 1, Michael Aitchison 6

1 The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
2 Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
3 Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK
4 University Hospital Southampton NHS Foundation Trust, Southampton, UK
5 NHS Greater Glasgow and Clyde Health Board, Glasgow, UK
6 Royal Free London NHS Foundation Trust, London, UK
* Corresponding author Email: naeem.soomro@nuth.nhs.uk


Funding: {{metadata.Funding}}

{{metadata.Journal}} Volume: {{metadata.Volume}}, Issue: {{metadata.Issue}}, Published in {{metadata.PublicationDate | date:'MMMM yyyy'}}

https://doi.org/{{metadata.DOI}}

Citation:{{author}}{{ (($index < metadata.AuthorsArray.length-1) && ($index <=6)) ? ', ' : '' }}{{(metadata.AuthorsArray.length <= 6) ? '.' : '' }} {{(metadata.AuthorsArray.length > 6) ? 'et al. ' : ''}}. {{metadata.JournalShortName}} {{metadata.PublicationDate | date:'yyyy'}};{{metadata.Volume}}({{metadata.Issue}})

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