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Report finds that dasatinib and nilotinib appear to have statistically significant advantages in molecular and cytogenic response compared with imatinib as first-line treatments for chronic myeloid leukaemia. This finding relates to short-term (1- to 2-year) trial outcomes, and longer-term impacts on survival and other patient-relevant outcomes remain uncertain.
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T Pavey, M Hoyle, O Ciani, L Crathorne, T Jones-Hughes, C Cooper, L Osipenko, M Venkatachalam, C Rudin, O Ukoumunne, R Garside & R Anderson.
T Pavey 1,*, M Hoyle 1, O Ciani 1, L Crathorne 1, T Jones-Hughes 1, C Cooper 1, L Osipenko 2, M Venkatachalam 2, C Rudin 3, O Ukoumunne 1, R Garside 1, R Anderson 1
1 Peninsula Technology Assessment Group (PenTAG), University of Exeter, Exeter, UK
2 Matrix Evidence, Matrix Knowledge Group, London, UK
3 Department of Haematology, Royal Devon and Exeter Hospital, Exeter, UK
* Corresponding author Email: toby.pavey@pcmd.ac.uk
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