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Study found evidence of increased detection rates and reduced false-positive rates from cross-trimester repeated measures testing in screening for Down’s syndrome, but potential benefits need to be confirmed prospectively
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D Wright, I Bradbury, F Malone, M D’Alton, A Summers, T Huang, S Ball, A Baker, B Nix, D Aitken, J Crossley, H Cuckle & K Spencer.
D Wright 1,*, I Bradbury 2, F Malone 3, M D’Alton 4, A Summers 5, T Huang 5, S Ball 1, A Baker 1, B Nix 6, D Aitken 7, J Crossley 7, H Cuckle 8, K Spencer 9
1 University of Plymouth, Centre for Health and Environmental Statistics, Plymouth, Devon, UK
2 Frontier Science (Scotland) Ltd, Kincraig, Inverness-shire, and Centre for Public Health Medicine, Queen’s University, Belfast, UK
3 Royal College of Surgeons in Ireland, Department of Obstetrics and Gynaecology, Dublin, Ireland
4 Department of Obstetrics and Gynaecology, Columbia University, New York, USA
5 North York General Hospital, Toronto, Canada
6 Cardiff University, Department of Epidemiology, Statistics and Public Health, University of Wales College of Medicine, Cardiff, UK
7 Institute of Medical Genetics, Yorkhill NHS Trust, Glasgow, UK
8 University of Leeds, School of Medicine, Leeds Screening Centre, Leeds, UK
9 King George Hospital, Department of Clinical Biochemistry, Essex, UK
* Corresponding author Email: dave.wright@plymouth.ac.uk
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