Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT

Maheshwari, Abha; Bari, Vasha; Bell, Jennifer L; Bhattacharya, Siladitya; Bhide, Priya; Bowler, Ursula; Brison, Daniel; Child, Tim; Chong, Huey Yi; Cheong, Ying; Cole, Christina; Coomarasamy, Arri; Cutting, Rachel; Goodgame, Fiona; Hardy, Pollyanna; Hamoda, Haitham; Juszczak, Edmund; Khalaf, Yacoub; King, Andrew; Kurinczuk, Jennifer J; Lavery, Stuart; Lewis-Jones, Clare; Linsell, Louise; Macklon, Nick; Mathur, Raj; Murray, David; Pundir, Jyotsna; Raine-Fenning, Nick; Rajkohwa, Madhurima; Robinson, Lynne; Scotland, Graham; Stanbury, Kayleigh; Troup, Stephen

doi:10.3310/AEFU1104

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A policy of freezing all embryos followed by thawing and transferring them at a later stage instead of fresh embryo transfer did not increase the healthy baby rate.

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Abha Maheshwari ^1,^*, Vasha Bari ², Jennifer L Bell ², Siladitya Bhattacharya ¹, Priya Bhide ³, Ursula Bowler ², Daniel Brison ⁴, Tim Child ⁵, Huey Yi Chong ¹, Ying Cheong ⁶, Christina Cole ², Arri Coomarasamy ⁷, Rachel Cutting ⁸, Fiona Goodgame ², Pollyanna Hardy ², Haitham Hamoda ⁹, Edmund Juszczak ^2,¹⁰, Yacoub Khalaf ¹¹, Andrew King ², Jennifer J Kurinczuk ², Stuart Lavery ¹², Clare Lewis-Jones ¹³, Louise Linsell ², Nick Macklon ^14,¹⁵, Raj Mathur ¹⁶, David Murray ², Jyotsna Pundir ¹⁷, Nick Raine-Fenning ¹⁸, Madhurima Rajkohwa ¹⁹, Lynne Robinson ²⁰, Graham Scotland ¹, Kayleigh Stanbury ², Stephen Troup ²¹

¹ Aberdeen Fertility Centre, NHS Grampian and University of Aberdeen, Aberdeen, UK
² Clinical Trials Unit National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
³ Assisted Conception Unit, Homerton University Hospital NHS Foundation Trust and Queen Mary University of London, London, UK
⁴ Assisted Conception Unit, Manchester University NHS Foundation Trust, Manchester, UK
⁵ Oxford Fertility, The Fertility Partnership, University of Oxford, Oxford, UK
⁶ Complete Fertility Centre, University of Southampton, Southampton, UK
⁷ Institute of Applied Health Research, University of Birmingham, Birmingham, UK
⁸ Human Fertilisation and Embryology Authority, London, UK
⁹ Assisted Conception Unit, King’s College Hospital, London, UK
¹⁰ Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, UK
¹¹ Assisted Conception Unit and Centre for Pre-implantation Genetic Diagnosis, Guy’s and St Thomas’ Hospital and King’s College London, London, UK
¹² Assisted Conception Unit, Imperial College London, London, UK
¹³ Fertility Network, London, UK
¹⁴ London Women’s Clinic, London, UK
¹⁵ Gynaecology, University of Copenhagen, Copenhagen, Denmark
¹⁶ Assisted Conception Unit, St Mary’s Hospital, Manchester, UK
¹⁷ Assisted Conception Unit, St Bartholomew’s Hospital, London, UK
¹⁸ The Fertility Partnership Nurture Fertility, Nottingham, UK
¹⁹ CARE Fertility, Birmingham, UK
²⁰ Gyanecology and Assisted Conception, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, UK
²¹ Reproductive Science Consultancy, Wilmslow, UK
^* Corresponding author Email: abha.maheshwari@abdn.ac.uk

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